Folate, also known as Vitamin B9, helps support a healthy pregnancy and fetal development. Additionally, folate helps support healthy protein metabolism, digestive and immune system functions, and formation of red and white blood cells. Research supports the use of folic acid to minimize risk of neural tube defects (NTDs), which are serious birth defects of the spinal cord and the brain, during pregnancy.
It is important to understand the differences between folate and folic acid. Folic acid refers to the oxidized synthetic compound used in dietary supplements and food fortification, whereas folate refers to the various tetrahydrofolate derivatives naturally found in food; tetrahydrofolate (or THF) is the form of folate that can enter the main folate metabolic cycle. Unlike natural folates (from food sources) that are metabolized to THF in the small intestines, synthetic folic acid must undergo initial reduction and methylation in the liver, where it is converted to THF in the presence of the enzyme, dihydrofolate reductase (DHFR).
However, because DHFR has low activity in the human liver, insufficient amounts of synthetic folic are converted to the THF form, resulting in unnatural, and potentially harmful, levels of unmetabolized folic acid entering the circulatory system. So, when adequate folate consumption from dietary sources is not an option, it is best to find a folate supplement made with food sources.
Despite this, almost all commercially available folic acid supplements are synthetically created in labs from industrial chemicals, which not only have very low bioavailability, but are potentially harmful when consumed in high doses.
By contrast, our product is a 100% natural source of Vitamin B9 as folate. The folate in our product is sourced from certified organic Citrus limon and is one of very few products on the market today that contains NO added synthetic folic acid.